Program

12:00- 

Check In/Registration

Lobby

17:00-19:00

Dinner

Rose Hall

Session I:

Welcome Session

(Chairs: Prof. Juan Du & Zhaozhu   Qiu)

Peace Hall

19:00-19:35

Role of VGCC in opening fusion   pore for Ca²⁺-independent but Voltage-dependent secretion in   neurons and endocrine cells

Zhuan Zhou

19:35-20:10

Mechanism of GPCR-transducer   coupling and basis of biased signaling

Eric Xu

20:10-20:35

Activation mechanism of GPCR dimers

Jianfeng Liu

20:35-21:00

Molecular basis of the PIP₂-dependent   regulation of N-type CaV2.2 channel

Byung Chang Suh

Oct   14 (Saturday)

8:00-8:20

Opening Ceremony

Peace Hall

8:20-8:40

Group Photo

Peace Hall

Session II:

Chloride Channels: Structure,   Function, and Diseases

(Chairs: Prof. Hailing Zhang &   Zhenhua Shao)

Peace Hall

8:40-9:15

The TMEM16F calcium-activated   ion channel and lipid scramblase

Lily Jan

9:15-9:40

Structural basis of TMEM16 lipid   scrambling

Alessio Accardi

9:40-10:05

Bestrophins: structure, function and diseases

Tingting Yang

10:05-10:25

Coffee Break

Session III:

Mechanosensitive Channels in   Sensory Physiology

(Chairs: Prof. Ming Zhou & Jing   Li)

Peace Hall

10:25-11:00

Mechano-sensitive channels in   sensory physiology and development

Yuh-Nung Jan

11:00-11:35

Feeling Force with PIEZOs

Bailong Xiao

11:35-12:00

TMC1/2 and TMEM63 superfamily of   mechanosensitive ion channels

Zhiqiang Yan

12:00-13:30  

Lunch

Rose Hall

Session IV:

TRP Channel Stoichiometry,   Evolution, and Gating

 (Chairs: Prof. Jie Zheng & Shilong Yang)

Peace Hall

13:30-13:55

A pentameric TRPV3 channel with a dilated pore

Simon Scheuring

13:55-14:20

TRPA1 Channel: Mechanisms of Activation and   Block by Non-covalent Ligands

Jun Chen

14:20-14:45

Structural evolution of TRPM2: from   channel-enzyme to molecular sensor

Wei Lü

14:45-15:10

Biophysics of supersensitive central heat   detection by TRPM2 channels

Laszlo Csanady

15:10-15:35

Structural mechanisms of TRPM7 activation and   inhibition

Alexander Sobolevsky

15:35-15:55

Coffee break

Session V:

Ion Channels and Receptors in Drug   Discovery

(Chairs: Prof. Kewei Wang &   Xuechuan Hong)

Peace Hall

15:55-16:20

Membrane Ion Channels -from Basic Research to   Drug Discovery

Xiaoliang Wang

(Weiping Wang)

16:20-16:45

Novel Drug Leads of α*-Conotoxins Targeting   Nicotinic Acetylcholine Receptors

Sulan Luo

16:45-17:10

Drug development targeting SARS-CoV-2 envelop   protein (2-E) channel

Zhaobing Gao

17:10-17:35

Functional screening and rational design of   compounds targeting GPR132 to treat diabetes

Jinpeng Sun

17:35-18:00

GPCR Signaling: Structure and Rational Drug Design

Yan Zhang

18:00-19:30

Dinner

Rose Hall

19:30-21:00

Poster Session

Peace Hall

21:00-

Social Hour

Oct   15 (Sunday)

Session VI:

Voltage-Gated Sodium Channels and

Cyclic Nucleotide-Gated Channels

(Chairs: Prof. Jian Yang & Wei Zhang (M))

Peace Hall

8:00-8:35

Targeting Nav channels for pain   relief

Nieng Yan

8:35-9:10

Assembly, Permeation, Gating,   and Pharmacology of Rod CNG Channel

Youxing Jiang

9:10-9:35

Allosteric modulation in cyclic   nucleotide-gated ion channels

Crina Nimigean

9:35-10:00

Structural understanding of HCN4 channel   permeation and gating

Anna Moroni

10:00-10:20

Coffee Break

Session VII:

Ion Channels in Health and Disease   I

(Chairs: Prof. Yong Li & Cheng   Deng)

Peace Hall

10:20-10:45

Regulation of Cav3.2 T-type calcium channels   by USP5: a new target for treating chronic pain

Gerald Zamponi

10:45-11:10

Lipotoxicity in the mechanisms of   Arrhythmias

Hsiang-Chun Lee

11:10-11:35

Excitation-transcription Coupling   in Brain Mitochondria and Aging

Huan Ma

11:35-11:50

SWELL1 channel-mediated tonic GABA release   from astrocytes modulates cocaine reward

Junhua Yang

11:50-12:05

Combined alcohol and cannabinoid exposure   leads to synergistic toxicity by affecting cerebellar Purkinje cells

Guichang Zou

12:05-13:30  

Lunch

Rose Hall

Session VIII:

Emerging Technologies in Ion   Channel Research

(Chairs: Prof. Fan Yang &   Huaiyu Yang)

Peace Hall

13:30-14:05

Hacking the ubiquitin code to control ion channel   functional expression

Henry Colecraft

14:05-14:30

Functional dynamics of cation channels studied   in liposomes by solid-state NMR

Adam Lange

14:30-14:55

Measuring conformational equilibria in   allosteric proteins with time-resolved tmFRET

William Zagotta

14:55-15:20

Spying on Neuromodulator Dynamics In Vivo by Constructing Multi-Color   Genetically-Encoded Sensors

Yulong Li

15:20-15:45

Ion permeation, voltage gating and   pharmacological modulation in K2P TREK channels studied by atomistic   molecular dynamics simulations

Han Sun

15:45-16:10

Real-time traffic: new optical tools for   measuring the regulation of TRPV1 surface expression by nerve growth factor

Sharona Gordon

16:10-16:30

Coffee Break

Session IX:

Structural and Function of Diverse   Ion Channels

(Chairs: Prof. Yong Yang & Wei   Zhang (F))

Peace Hall

16:30-16:55

Functional characterizations of   CatSper auxiliary subunits

Jianping Wu

16:55-17:10

Structural Mechanisms of ATP Permeation and   Pharmacology into PANX1 ATP-release Channel

Zheng Ruan

17:10-17:25

A new polymodal gating model of the   proton-activated chloride channel

Cheng Tang

17:25-17:40

Structural basis for the orthosteric and   allosteric inhibition of P2X receptors

Motoyuki Hattori

17:40-17:55

Structure of UCP1, a purine   nucleotide-sensitive proton channel

Lei Chen

17:55-18:10

Structural insights into ion selectivity and   transport mechanism of plant HKT transporters

Huaizong Shen

18:10-19:30  

Dinner

Women Career Development

Rose Hall

19:30-20:30

Business Meeting

 (All Academic Committee Members)

Kaffir Lily   Hall

20:30-

Social Hour

Oct.   16 (Monday)

Session X:

Ion Channels in Neuronal Signaling

(Chairs: Prof. Tianle Xu &   Xiaona Du)

Peace Hall

8:00-8:35

Ion channel diversity:   alternative splicing under activity-dependent feedback control

Richard Tsien

8:35-9:00

AMPA glutamate receptor signaling   – auxiliary subunits and beyond

Ingo Greger

9:00-9:25

Regulation of GABA_A receptors by   transmembrane auxiliary subunits

Wei Lu

9:25-9:50

Visualizing putative ions and   water molecules in the ion conduction path of the AMPA receptor

Terunaga Nakagawa

9:50-10:05

Molecular Dynamics Simulations Reveal State   Dependent Interactions and the Allosteric Binding of Ketamine in NMDA   Receptor

Han Wen

10:05-10:25

Coffee Break

Session XI:

Ion Channels in Health and Disease   II

(Chairs: Prof. Wei Lu & Jing   Yao)

Peace Hall

10:25-10:50

Bilirubin gates the TRPM2 channel as a direct agonist   to exacerbate ischemic brain damage

Luyang Wang

10:50-11:15

Diverse NMDA receptor structures   illuminate synaptic function and brain disorders

Shujia Zhu

11:15-11:40

TRPM2 regulates vulnerability of dopaminergic   neuron in Parkinson’s disease

Wei Yang

11:40-12:05

Phasic/tonic glial GABA   differentially transduce for olfactory adaptation and neuronal aging

Lijun Kang

12:05-13:30  

Lunch

Rose Hall

Session XII:

From Evolution to Function:   Insights into Unique Ion Channels

(Chairs: Prof. Xiaoqiang Yao &   Ruotian Jiang)

Peace Hall

13:30-13:55

Otopetrin1 evolution confers sour   tolerance in birds

Ren Lai

13:55-14:20

Physiological roles and mechanisms   of voltage sensing phosphatase, VSP

Yasushi Okamura

14:20-14:45

Molecular mechanisms of the mitochondrial   calcium uniporter

Liang Feng

14:45-15:10

WeiTsing, a pericycle-expressed   ion channel, safeguards the stele to confer clubroot resistance

Yuhang Chen

15:10-15:25  

Coffee Break

Session XIII:

Potassium Channels I

(Chairs: Prof. Linhua Jiang &   Mingqiang Rong)

Peace Hall

15:25-15:50

Inactivation of the Kv2.1 channel   through electromechanical coupling

Kenton Swartz

15:50-16:15

The mechanism underlying protein   biogenesis of the hERG channel and pharmacological rescue of LQTS mutant   channels

Shiqing Cai

16:15-16:30

Stress induced Kcna5 gene expression in the   cerebellum

Yi-Mei Yang

16:30-16:55

A novel ion conducting route   besides the central pore in an inherited mutant of G-protein-gated inwardly   rectifying K⁺ channel

Yoshihiro Kubo

16:55-17:20

Comparison of hyperpolarization inward and   depolarization outward rectified K⁺ channels

Changlin Tian

17:20-17:35

Structural basis for ligand activation of   human KCNQ2 channel

Jiangtao Guo

18:20-18:35

VAI Poster Award

Peace Hall

18:35-

Closing Dinner

Oct.   17 (Tuesday)

Session XIV:

Potassium Channels II

(Chairs: Prof. Jianmin Cui & Yun   Shi)

Peace Hall

8:00-8:25

Regulatory subunits confer drug resistance to   Kv2 channels

Jon Sack

8:25-8:50

Intrinsic Opening of BK Channels Derives   from the Leakage in Hydrophobic Gating

Jianhan Chen

8:50-9:15

Structural Basis of Human KCNQ1 Modulation and   Gating

Ji Sun

9:15-9:40

Activation and closed-state inactivation   mechanisms of the human K_V4 channel

Chia-Hsueh Lee

9:40-10:05

Gating Modulation of KCNQ1 Channels by KCNE   Subunits: A Structure-guided Approach

Koichi Nakajo

10:05-10:25

Coffee Break

Session XV: Organellar Physiology   and Ion Channels

(Chairs: Prof. Michael X. Zhu)

Peace Hall

10:25-11:00

Proton release mechanisms in the   lysosome

Haoxin Xu

11:00-11:25

Lysosomes finely control macrophage   inflammatory function via regulating the release of lysosomal Fe²⁺   through TRPML1 channel

Wuyang Wang

11:25-11:40 

Closing Remarks

Peace Hall

11:40-13:30

Lunch

Rose Hall

13:30-18:00

Tour to Niushou Mountain